KIEV -- At least five people were killed and dozens others injured in a fresh Russian massive drone and missile attack on Ukraine on Wednesday, local authorities said.

Kiev was hit the hardest in the strikes that targeted six Ukrainian regions, according to Interior Minister Ihor Klymenko.

At least four people were killed and 40 others injured in the Ukrainian capital when debris from a missile hit an 18-storey building in the southern Holosiivskyi district, said the National Police.

Three people were injured and 58 private houses damaged in the Kiev region, said the regional military administration.

One person died and six others were wounded in the attack in the city of Mykolayiv in southern Ukraine, the regional police said in a statement.

Two people were also injured in the eastern Kharkiv region, said the State Service for Emergencies.

Russia fired 44 missiles, including cruise and ballistic missiles, and 20 Shahed combat drones at Ukraine, said the Ukrainian Air Force.

According to it, 29 missiles and 15 drones were downed by the air defense.